Today I have 6 supplements after SIBO antibiotics to share with you.

These days I believe that less is more so when my doctor told me how well I was doing, I said,

Then let’s only do the things I need to keep me thriving and continue healing this SIBO for good.

Less is more…..and he agreed.

So here are the exact supplements after SIBO antibiotics that I did.

BTW: This post has been updated as of January 3, 2024. I am still healed today and have never had a SIBO setback since I wrote this.

Okay, then… you go.

6 Supplements After SIBO Antibiotics

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6 supplements after SIBO antibiotics

HCl with Pepsin

I have been taking this one for a very long time now.

The doctor and I both agreed that in order to keep gaining on the stomach acidity, this one is critical for long-term SIBO recovery.

Part of my issue with relapse is that my stomach acid is low.

I start feeling so great after the antibiotics that I get lazy with taking the HCl with Pepsin and ultimately, I relapse.

In order to keep healing, I need to take this, consistently, with higher-protein meals.

The amount I take is different than what you might take.

You can learn more about stomach acidity and how to tell if yours is low via: 33 Ways to Tell if You Have Low Stomach Acid and How to Test at Home for Low Stomach Acid

Increase Now from A Gutsy Girl and betaine HCl with Pepsin

Get high-quality Betaine HCl + Pepsin today + use code ‘BLOG’ at checkout to save 15%.

Digestive Enzymes

I take these before most meals; not snacks, meals (unless the snack is pretty complex and/or larger).

Digestive enzymes aid in breaking food down.

Over the years, people have said that “you shouldn’t rely on them…blah, blah, blah.”

Well guess what? Those people were not doctors and I’ve never had a doctor tell me they aren’t effective and/or helpful for continued healing.

I do not rely on them by any means, but I believe they help the digestive process so food breaks down appropriately to pass through the digestive tract without any hang ups. 

Get instant help breaking your food down.

Break Down #digestiveenzyme #bloating


This is a brand new one for me. He wants me to take a dose twice per day, and he mentioned that when doing this, I don’t have to “double up” with L-Glutamine (though, I could take a little L-Glutamine, if desired).

The supplement features features 3 key ingredients—glutamine, deglycyrrhizinated licorice (DGL), and aloe vera gel, and its purpose is to support the intestinal lining for healthy digestion, healthy immune function, and overall health.

Get this through ‘A Gutsy Girl’s’ Fullscript dispensary and save $$.


Note: Back when I wrote this post and gave the information as outlined below regarding WholeMune, I did end up taking it. I did not end up substituting for LDN at the time, however. That said, I believe that Tummy Soothe is a far superior product to WholeMune and would recommend that 100% over this one. Take that for what it’s worth to you.

This is the supplement I can use once per day in place of LDN.

WholeMune is formulated with Wellmune WGP®, the most well-researched, single beta-glucan, proven in clinical trials to prepare and protect the immune system from repeated and ongoing stressors.

Its purpose is for a strong immune system and overall health and wellbeing.

I have not started it yet but will as soon as my current LDN bottle is finished. I’ll give it a one month test period, and then re-evaluate.

Get Tummy Soothe today + use code ‘BLOG’ at checkout to save 15%.

Tummy Soothe #supplements


According to my doctor, a lot of people take this as “maintenance” for post-SIBO antibiotics to help ensure SIBO keeps at bay.

It supports gut healing, microbiome health, and the immune system.

He told me if I’m feeling perfect to not take it, but if I even feel a little off, to take it for one week, then have three weeks off.

Rinse and repeat as needed.


Probiotics, both during and after SIBO antibiotics, are highly controversial.

What’s the answer?

There isn’t AN answer because everyone responds differently to them, depending on their own situation.

For me personally, when I’m in a flare and/or on SIBO antibiotics, I do not take them. They only exacerbate any current symptom I have.

In the past, I have always avoided them after SIBO antibiotics as well because I thought they were inducing symptoms again.

I now believe this is because I needed a probiotic that didn’t contain prebiotics which is why I use the Just Thrive Probiotic now. And I love it! (p.s. If you enter in code AGUTSYGIRL at the Just Thrive checkout HERE, you’ll always save 15%!)

My FAVORITE probiotic also comes in the GUMMIES form now, too. Same, exact benefits!

Just Thrive probiotic

And that’s it.

Keeping it as simple as possible.

Hope this helps direct you in asking questions to your own doctors.

Write down the supplements above that you’re curious about and note them in your 28-day gut healing journal for your next appointment.

By the way, if you want a minimalist approach to supplements, check THIS out.

If you liked this post, you might also enjoy:

  1. 15 Supplements for Stomach Lining Support
  2. Reasonable SIBO
  3. Fight a Virus by Protecting Your Gut 


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  1. Hi Sarah. I’ve been building up on my HCL with pepsin. I’m up to 4 per meal, with no side effect yet. My question is with this supplement help with motility??
    Also, in the meantime, I purchased intentional movement formula. How many do I need to take for it to be successful? ( I realize even e is different) but, how many do you have to take?
    Thanks so much!
    So enjoying your book!!! ????

    1. Hi – HCL helps break down protein and food so that, yes, it can help with motility. The Intestinal Movement bottle says you can take 2. I only take 1 when I need it and it works great. You can follow what the bottle says, take one, or (best yet) see what your doctor says. Xox

  2. I don’t see any comments regarding the dysbiocide in the post! Just curious as to why you’re taking disbiocide in sibo recovery as this is also part of a common treatment protocol. It could be the website not formatting to my phone, but either way I’d love to know. Thanks!

  3. Hi Sarah. Could you please give me any suggestions for repairing leaky gut for 6year old child.
    I have investigated a lot on line but still any suggestions would be beneficial. If you could read and give me your idea about my leaky gut protocol I would be so happy to send it to you by email.
    Thank you !

  4. Hi Sarah,

    Do you start taking a probiotic right after you finish xifaxan? Just curious because I worry about relapse.

      1. Thank you. My GI said do not take one. My functional medicine doctor said take a spore probiotic so I am confused. I do take motegrity for motility. I just wasnt sure if I sure start a probiotic to start to repair my gut. Thank you!

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