If I had a nickel for each time someone asked, “Should I take a probiotic with SIBO?” I might be a millionaire.
Taking probiotics with SIBO is a controversial topic, and that’s because no two SIBO cases are exactly the same. Therefore, every single thing you read (yes, even this post) is subjective.
But let me just tell you that I have done it all.
I have taken probiotics with SIBO and I have not taken probiotics with SIBO. Additionally, I have tried various types of probiotics. So today, I want to give it to you straight – what I’ve done and what has worked in my experience.
Here is some information on what other people say on the issue.
- The SIBO Guru says that probiotics are “absolutely necessary.”
- Amy Myers MD says to go with a “soil-based probiotic.”
- Chris Kresser often sits on both sides of the fence.
- Dr. Michael Ruscio says probiotics benefit those with SIBO and IBS.
- Psychology Today cautioned the use of probiotics with SIBO.
So what do I think?
Again, I’m only speaking from tried, tested, and true trial-and-error.
Should I Take a Probiotic with SIBO
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Whether or not you take a probiotic with active SIBO depends on these three main things:
- What is the root cause?
- What stage of SIBO healing are you in? How are your daily symptoms?
- Which probiotic are you taking?
Let’s first address #1: What is the root cause?
According to Neuroscience News,
Probiotic use may be particularly problematic for patients who have known problems with motility, as well as those taking opioids and proton pump inhibitors, which reduce stomach acid secretion and so the natural destruction of excessive bacteria.
This helps explain why probiotics, at certain times during my healing journey, made me miserable. My bottleneck is motility and reduced stomach acid. If this is your root cause, too, this could be the reason you also aren’t tolerating probiotics.
Sometimes, SIBO is triggered after an illness while traveling abroad. In that case, a probiotic may be beneficial once you take into consideration the other things below.
The key here is that you must know your root cause. So often, though, we never know the root cause, which probably contributes to a probiotic “not working.”
#2: What stage of SIBO healing are you in? Symptoms?

I can only speak to this one from 100% experience.
When I was first diagnosed and/or every time I would relapse, everyone said, “You need to take a probiotic especially if you’ve been on Rifaximin for a month.”
So I did. It never helped; in fact, I think it made me worse.
Over time, I have learned that when SIBO relapses I must completely remove the probiotic. If I even feel a hint of SIBO trying to relapse, I remove the probiotic. Works like a charm; every single time.
Your takeaway here: listen to your body. What is it telling you today? If it’s in misery, consider dropping that probiotic.
#3: Which Probiotic are you taking?
Dr. Amy Myers says that for those with SIBO, a soil-based probiotic is best.
Soil-based probiotics do not exacerbate symptoms of SIBO in the way other types of probiotics can. In fact, one clue that you may have SIBO is that when you take a probiotic containing lactobacillus or bifidobacterium you have an exacerbation of your symptoms such as more gas, bloating, constipation, diarrhea or other digestive symptoms. If you are currently dealing with SIBO, it’s not recommended to take a probiotic containing lactobacillus or bifidobacterium strains until you’ve eliminated your bacterial overgrowth and repaired your gut, as these can actually worsen your SIBO.

Some Soil-Based Probiotics
- Ancient Nutrition Probiotic
- Megasporebiotic
- Prescript-Assist (however, I can’t find it anywhere anymore)
- Primal Blueprint (used this one in the past)
Equilibrium is a super high quality probiotic (though they say it’s not 100% soil-based) that I have taken throughout the years, at different times on my journey.
Besides the soil-based probiotics, one other thing to look for and ask yourself is:
Does the probiotic contain prebiotics as well?
Remember, there is a difference between probiotics and prebiotics.
While some sources will tell you to only use a probiotic that contains prebiotics, you must know that for those with SIBO, this is not always the best strategy.
Prebiotics are full of fiber and help feed bacteria. Are you in a place where you want that?
Personal Probiotic Usage Update in 2020
Post-Expo West in 2019 I began taking the Just Thrive Probiotic.
Since then, I have never looked back. And I continue to recommend it to almost everyone – it’s been incredible for our entire family.
You can learn more it:
Save 15% off the Just Thrive Probiotic by entering in code ‘AGUTSYGIRL’ at checkout.
Final Thoughts
Probiotics can be incredible for overall gut health. I have written all about it HERE. The problem is when digestive “experts” try to put all digestive systems into one bucket because:
- Not all are healthy, and
- No two are the same.
Reading digestive information online is meant to be a starting, not conclusive, place for you.
If all the rage are probiotics and how wonderful they are, take a step back and do some critical thinking on it while practicing via your own trial-and-error. Then, listen to your own body.
My stomach has always told me if and when it’s ready for a probiotic.
Today? Yes, yes I am taking a probiotic daily. I believe it’s helping me thrive, but I’m also on the other side of SIBO h#$%.
Questions? Thoughts? Leave them in the comments below.
If you liked this post, you might also enjoy:
Xox,
SKH

You will heal. I will help.
My functional med doctor wants me to retest bc my sxs have improved big time w oregano and peppermint oil and low fod map diet . He wants me to start specific probiotic as soon as I do breath test . He said it helps kill the sibo so we shall see!!
Good luck! Let me know how it works for you.
I am currently on Flagyl as Rifaxamin produced little results. I take Align probiotic. Plus Colace abd Kow FODMAP diet. Only some improvement thus far. Suggestions? I also have restless legs, sleep apnea, and GERD which seem to be related to my gut issue. I keep gaining weight!
Consider dropping the probiotic?
Try Candibactin AR & BR. You take it with meals and full glass of water three times a day for a month. Read the thousand reviews on Amazon to get a feel for its success. I get mine from Metagenics, which is a very respectable company, but Amazon has so many people’s stories. If you google it on Mayo clinic, it’s efficacy is actually higher than Rifaximin and it is not an antibiotic.
Restless leg I used to get also; rub Magnesium cream on them at night and be sure to be fully hydrated. Mg can get low with poor absorption of nutrients during bowel flares. Also could be low iron according to my doctor- make sure u take a quality multivitamin like, Innate.
Good luck!
Didnt you say dont take a probioitc with prebioitcs? Then you said your taking ‘Just thrive’. It contains prebioitcs…..
Hi Steven – The Just Thrive Probiotic doesn’t contain prebiotics. They do, however, have a separate prebiotic.
I was a faithful consumer of Align -before and up to getting SIBO. I thought it would help but it only made things worse. I dropped the Align, treated SIBO with Rifaximin and Neomycin, then attempted to take Align again. I could feel my stomach rumbling and I knew it was making things worse, not better. I treated SIBO back in June and I’ve been afraid to take another probiotic. I may try a soil-based one next but I have to say that I’ve been doing well without them. Fingers crossed that SIBO doesn’t return!
Have you ever had or heard of a probiotic triggering acne?
Absolutely!
Sarah,
Just wanted to throw it out there that Cedars Sinai cautions against them.
I look at history. I see how bad the situation has become, and by that I mean how much more common. I see that happening in conjunction with the increased promotion of probiotics. *shrugs* It’s just my opinion, but maybe it’s not just a coincidence.
I have SIBO among various digestive issues. I was on Prescript Assist until the formula changed. Prescript Assist was The answer to all my problems. Since the change in formula I have been on numerous probiotics managing to gain 10 pounds.
Now I am suffering from either weight gain or acne while taking probiotics. I have had two bouts of acne in a year.I am suffering with breakouts now while on PROBIOTIC 225. Last summer I broke out while on GutPro. I am almost 66 years old and have not had acne in decades.
Do you know what particular strain in probiotics triggers acne breakouts??? I would like to avoid probiotics with this strain.
Thank you.
Hi! I inquired for you, and here is what I have to share with you: “Does your probiotic contain lactobacillus strains? Those can worsen SIBO symptoms or any gut condition involving an overgrowth of lactobacillus strains including Crohn’s. Just Thrive does not contain any of those strains. Just Thrive is comprised of 4 strains of Bacillus Endospores, which have been in the pharmaceutical market in 2/3 of the world for the last 60 years. One of the strains has been used to treat SIBO. The four strains are Bacillus Indicus, Bacillus Coagulans, Bacillus Clausii and Bacillus Subtilis.The Bacillus Indicus HU36 actually produces RDA levels of antioxidants in the gut. Such as alpha and beta carotene, lycopene, lutein, astaxanthin and zeaxanthin. Just Thrive is all natural, gluten free, dairy free, sugar free, non gmo, vegan, and nut free.” Hope that helps!
Bacillus HU36®, being a spore, offers advantages of better colonization and survival through the digestive track when compared to non-spore probiotic organisms; it also offers claims related to the most bioavailable form of antioxidants and carotenoids.
More details:
https://www.synergialifesciences.com/bacillus-indicus-strain-spore-probiotic-HU36.html
Hi there! Love the probiotic info , thank you.
I have been dealing with SIBO for a year now and have learned a lot.
Just want to ask you if you have tried Candibactin AR and BR in eradicating the bad bacteria instead of Rifaximin?
Nice healthy alternative ….I get mine from Metagenics . But I’m glad I read ur article bc I have been trying to figure out the “die off” stage and how to reinocculate bowel with good bacteria. Also, how strict are you with diet? They all say get rid of carbs and sugar- very hard for me , but I try …
Hi Kelsey – No, I have not tried them. As for diet – during the antibiotics, I mostly ate everything. Afterwards, I backed off a little. And today, now that I’m healed? I eat anything and everything freely.
Hi Sarah
which probiotic should I take with Stomach mobility and SIBO.
Gut pro made things worst as well as Custom Probiotics and may MegaSporeBiotic. I used so many I don’t even remember the brand but never used Just thrive.
Thanks for your post.
Christelle
Hi! I’d recommend working with your doctor. Many people love the Just Thrive one, me included, BUT everyone is different. The other thing you could try is not taking a full capsule at once. I have a blog post on this website about troubleshooting your probiotic. Hope that helps. Xox