Today I’m dissecting Digest Plus. And I am genuinely excited about this one.
No sarcasm, even though my life often feels like one long sarcastic reel.
Here’s why the excitement is real: this formula has been one of my own favorite healing supplements for years. I’ve mentioned it across many posts, including How I Achieved a Year of Perfect Gut Health. I knew generally why it worked. I never sat down and broke it apart, herb by herb, until now.
And now it’s mine.
Dissecting Digest Plus: A Gut-Healing Herbal Formula for SIBO
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Introducing Digest Plus
Digest Plus is the newest addition to the Gutbyome line, my own Gut Healing Supplements brand. It’s a proprietary blend of Eastern and Western herbs and herbal extracts that support normal gut health, chosen for their work on the kind of dysbiosis that drives bloating, gas, and SIBO.
I didn’t formulate something trendy from scratch. I took a blend I already trusted, already used, already recommended, and brought it under my own roof so I could stand behind every capsule.
The combination of Eastern and Western herbs gives this formula a broad anti-dysbiotic effect, even at low dosing. That’s the short version. Let’s get into the actual herbs, because the education is the point.
Dissecting Digest Plus: the ingredients
I’m breaking down each botanical so you understand why this formula is as potent as it is.
Dill (Anethum graveolens) (seed)
Common in Ayurvedic medicine for abdominal discomfort, colic, and digestion. It’s the herb in gripe water, the stuff given to ease colic and flatulence in babies and young children.
In Body Into Balance: An Herbal Guide to Holistic Self-Care, dill is listed as a carminative. Carminatives improve digestion, dispel gas, ease bloating, and calm cramps. Others in that family: lemon balm, thyme, holy basil, cardamom, peppermint, fennel, bee balm, lavender, catnip, and ginger.
Stemona (Stemona sessilifolia) (root) (powder and extract)
Information on Stemona sessilifolia isn’t easy to find. What’s documented about Stemona as a genus tends to focus on the lungs and respiratory conditions.
But you’ll also find it noted for destroying intestinal worms and expelling gas. The fact that it’s the second ingredient listed tells you there’s something fairly powerful here.
Wormwood (Artemisia absinthium) (shoot & leaf) (extract)
A digestive bitter that supports healthy appetite and GI function. It also supports a healthy flora balance in the digestive tract.
More on bitters in the Gut Health Guide to Digestive Bitters.
Java Brucea (Brucea javanica) (fruit) (powder & extract)
In traditional Chinese medicine, java brucea seed has bitter, cold, and slightly toxic properties. It associates with the Large Intestine and Liver meridians.
Chinese Pulsatilla (Pulsatilla chinensis) (rhizome) (powder & extract)
One of the 50 fundamental herbs in traditional Chinese medicine. It’s been used to clear heat, cool the blood, resolve fire toxicity, relieve dysentery, and ease abdominal pain.
Pulsatilla root benefits the digestive system, supports female health, and supports the lymphatic system. It carries antimicrobial, anti-parasitic, antibiotic, and anti-amebic properties.
Jamaica Quassia (Picrasma excelsa) (bark) (extract)
Also called Bitter Wood. Its bark contains quassin, a compound 50 times more bitter than quinine. It’s the bitterest naturally occurring chemical we know of.
Quassia has strong implications for food digestion and can ease diarrhea caused by dysentery. It helps food pass through the digestive system at the right rate for proper nutrient absorption.
Cutch Tree (Acacia catechu) (heartwood & bark) (powder & extract)
A deciduous, thorny tree native to the southern Himalayas of Pakistan, northern India, and Nepal, south to Andhra Pradesh, and east into Burma and Thailand.
Its primary traditional use is for cough and sore throat, but it’s also used against dysentery, diarrhea, and for wound healing.
Hedyotis (Hedyotis diffusa) (aerial part) (powder & extract)
Most commonly associated with colorectal cancer, Hedyotis clears heat and eliminates toxins. As one of the last ingredients listed, it’s hard to know exactly how much the formula contains.
Yarrow (Achillea millefolium) (leaf & flower) (extract)
They say yarrow has a million uses. The name comes from the Greek warrior Achilles. You can use it internally and externally.
In this formula, yarrow likely earns its place through its antimicrobial properties and its ability to tighten and tone boggy tissue and support healing.
Digest Plus for SIBO
In 2014, when I was first diagnosed with SIBO, my California doctor put me on an herbal antimicrobial protocol. The main supplement then was GI Synergy. Over the next few years I cycled through various herbals, and nothing worked quite right.
After we moved back to Minnesota, I did a final round of Rifaximin and Neomycin. At the same time, my new doctor suggested the formula that’s now Digest Plus.
He had me do 7 days on, then the rest of the month off, for prevention and to hold the clear, healthy state I’d fought for.
I’d never heard of it. I was willing to try anything to finally kick SIBO to the curb.
Today I swear by it. For me personally, I use it for maintenance.

“During and after healing my SIBO, this was a staple product. 10+/10.” – SKH, AGG
What the herbal-versus-rifaximin research actually shows
This is the part people quote, so I want to give it to you straight.
A 2014 study out of Johns Hopkins looked at whether herbal therapy could hold its own against rifaximin, the antibiotic most associated with SIBO.1 It was a retrospective chart review of 104 patients with SIBO confirmed by breath testing, not a randomized trial, which matters for how much weight to put on it.
The herbal arm used a two-product combination (the Digest Plus formula together with a companion antimicrobial blend), at 2 capsules of each, twice a day, for 4 weeks. The result: 46% of the herbal group cleared SIBO on follow-up breath testing, compared to 34% on rifaximin. The difference wasn’t statistically significant, which is the honest way of saying the herbs held their own.
Two things I want you to hold onto. First, that result came from the combination, not from any single bottle. Second, “equivalent” means the herbs performed comparably, not that they’re a miracle or a guaranteed cure.
SIBO is stubborn, and no capsule replaces addressing the root cause, whether that’s motility, low stomach acid, or structural issues.
Coming soon: the full combination
You read that right. The study that put this formula on the map used two products together.
Right now, Digest Plus is the first half, and it’s available today! The companion antimicrobial blend is coming to the Gutbyome line soon, so you’ll be able to run the full combination, both halves under my own label, start to finish.
When it lands, I’ll walk you through that formula the same way I just did this one. Want first word? Just make sure you’re on the Supplement newsletter list.
Side effects and warnings
I have never had a single side effect from this formula. That doesn’t mean you can’t, so read this part.
Not recommended for pregnant or lactating women. May cause mild constipation in sensitive individuals; if it persists, stop and contact your healthcare professional. Wormwood (Artemisia absinthium) is not recommended alongside blood-thinning drugs, drugs that reduce stomach acid, or drugs that prevent or lessen seizures. Wormwood may intensify the effects of alcohol. Keep out of reach of children.
As always, work with your own doctor before adding this in, especially if you’re on medication or managing a diagnosis.
Have you used a similar formula before? I’d love to hear your experience in the comments.
If you liked this post, you might also enjoy:
- Best Supplements for SIBO (based off experience + research)
- Reasonable SIBO
- Printable SIBO Diet (Reasonable SIBO, Heal Your SIBO)
Xox,
SKH

I had methane dominant SIBO and I used dysbiocide and FC Cidal for my first round. I had amazing digestion, but then I got too cocky with my food so I had a relapse and it no longer worked. That’s when I switched to Candibactin AR and BR. That finally eradicated the SIBO. However, that is a powerful herbal so I have dysbiocide and FC Cidal in my medicine cabinet in case I ever feel my stomach is off for more than 2-3 days!
How do you use the dysbiocide for maintenance?
You used this as a weeding protocol? Were you taking anything else along with it? Ie. Enzymes etc
Yes, I was doing all of my other things – the HCL and enzymes namely.
I basically just take it every now and then for a few days on 🙂
What brand of HCL and enzymes were you taking?
Hi Anne! You’ll find all of that here 🙂 –> https://a-gutsy-girl.ck.page/8efa86ceff
My ND has me on Ibogest and HCL as maintenance. Would it be ok to add this suppler too? Or am I double dosing?
Ask your ND for sure 🙂
Would you recommend this for IMO (Methane dominate SIBO- Intestinal Methanogen Overgrowth) Thank you
That’s what I had – Methane dominant.
Hi there,
Did you take neomycin and Refaximin to heal ? How did you feel during treatment, any side effects?
Thank you
Regards,
Anna
Yes, I did! See the post on this site called –> My 28-Day Rifaximin and Neomycin Journal. That will really help you 🙂
Should I take with or without food?
Ask your doctor 😉
Did you take the Dysbiocide immediately following the antibiotic treatment? or did you wait a few days?
How do these compare with Biociden? I recently purchased it. I have Hydrogen dominant SIBO.
Do you know where else I can purchase this? The Amazon link says that it’s currently unavailable.
Hi Leah – I do not. Here is what I do know. I started getting emails with the same question once people found it out via Amazon. So I reached out to the company. They said they have no control over when Amazon will have it again. They also said that unless you have a practitioner account, you can’t even order it directly from their website. So, I submitted my credentials and I’m now able to obtain it. However, I’m still not sure how I would get it to people once I ordered a lot of it. Feel free to email me directly in case I figure out a way around it.
Is this product safe for children (8 years old). I realize it says to keep out of reach of children but is that because they could take too many without supervision or is it not recommended at all for children.
HI Carrie – You should definitely check with your pediatrician.