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If you’ve ever stood in the supplement aisle staring at 47 different fish oil bottles wondering which one won’t make you burp or break the bank, you’re not alone.

Here’s what nobody tells you: the $15 fish oil and the $45 fish oil might contain the same amount of omega-3s — but your body can’t necessarily use them the same way.

That’s the difference between wasting money and actually healing.

Fish oil shouldn’t be confusing.

[Though the supplement industry seems determined to make it that way.]

And you definitely shouldn’t have to gamble with your gut.

The truth? Most fish oils are fine.

But fine doesn’t cut it when you’re dealing with chronic bloating, inflammation, or hormonal chaos that feels like it has its own zip code.

You deserve something better than fine; one that actually works.

Let’s break down exactly what to look for so you can choose wisely, feel confident, and actually see results.

What to Look for When Purchasing a Fish Oil (So You Don’t Waste Money on One That Won’t Work)

Click HERE to save this article for later.

The 5 Non-Negotiables for Choosing a Gut-Friendly Fish Oil

If you take nothing else from this article, take these:

✔ Triglyceride or re-esterified triglyceride (TG or rTG) form

Your gut absorbs this form significantly better than ethyl ester forms. This matters for women with compromised digestion.

✔ 1000–1500 mg combined EPA + DHA

This is the therapeutic range for inflammation support, hormone balance, and gut healing. Anything less won’t move the needle.

✔ Small-fish sourcing (anchovy and sardine are best)

Smaller fish = cleaner fish. They accumulate fewer toxins and heavy metals than larger fish like tuna or salmon.

✔ No artificial flavors or unnecessary additives

If your gut is sensitive, you don’t need mystery ingredients. Clean formulas = better tolerability.

✔ Brand transparency + third-party testing

Look for brands that voluntarily test for purity, oxidation levels, and heavy metals. If they’re not transparent about testing, move on.

Quick gut check:

How many of these boxes does your current fish oil check? If it’s fewer than 4, keep reading — I’ve got better options for you below.

Save this checklist — screenshot it, print it, tattoo it on your arm. [Kidding on that last one. Mostly.]

Why Form Matters More Than You Think

Here’s what most people don’t know: not all omega-3s are created equal.

Fish oil comes in different molecular forms, and the form determines how well your body can actually use it.

Triglyceride (TG) form: This is the natural form found in fish. Your body recognizes it easily and absorbs it efficiently.

Re-esterified triglyceride (rTG) form: This is TG that’s been concentrated, then converted back to triglyceride form. It offers high potency with excellent absorption.

Ethyl ester (EE) form: This is a synthetic form created during processing. It’s cheaper to make, but your gut has to work harder to break it down — and absorption rates are lower, especially if you have digestive issues. [This is exactly why I felt nothing from most fish oils before creating More Omega.]

For women with gut challenges? TG or rTG form is non-negotiable.

The AdvoCare OmegaPlex Question

This entire article came about because someone who gets my Supplement Sunday emails asked my thoughts on AdvoCare OmegaPlex.

So let’s address it.

What OmegaPlex is:

OmegaPlex is AdvoCare’s omega-3 fish oil supplement containing EPA and DHA — the two omega-3 fatty acids most associated with inflammation support, hormone balance, and cellular health.

What OmegaPlex isn’t:

Here’s where the gut-sensitive woman needs to pay attention.

OmegaPlex does not emphasize three things that tend to matter for absorption, purity, and tolerability:

• It does not use the triglyceride (TG or rTG) form, which your gut absorbs more easily
• It does not highlight small-fish sourcing (anchovy/sardine) — the cleanest option for most guts
• It does not match the high-potency EPA + DHA levels found in many of today’s gold-standard formulas

Is OmegaPlex a bad product? No.

But is it the best option for women with gut challenges, inflammation, or a need for higher-absorption omegas? Probably not.

Why We Created More Omega (And Why You Still Ask About It)

When we first developed More Omega for my supplement line, Gutbyo[me], the goal was never “just another fish oil.”

It was designed for the woman who:

• has tried fish oil before but felt nothing
• reacts to additives, flavors, or heavy oils
• needs clean, concentrated EPA + DHA
• wants strong absorption without digestive upset

More Omega checked all the boxes:

• Triglyceride (rTG) form for superior absorption
• High potency EPA + DHA
• Small-fish sourcing
• Clean, minimal excipients
• Gut-friendly tolerability

In short: It was built for the woman who wants to feel a difference — not just swallow another supplement.

And yes… we know. It was a community favorite. It sold out over and over again. You still message us asking when it’s coming back.

But since More Omega is no longer available, we did the next best thing: We researched the market and found the closest possible replacements.

Here's exactly how OmegaPlex stacks up against More Omega:
[I pulled the actual supplement facts panels for this comparison.]

[After doing all of this research, though, I’m feeling like More Omega needs to make a comeback?!]

Feature	OmegaPlex (AdvoCare)	More Omega (Gutbyo[me])
EPA per 2 softgels	600 mg	750 mg
DHA per 2 softgels	400 mg	750 mg
Total EPA+DHA	1000 mg	1500 mg
EPA:DHA ratio	~1.5 : 1	1 : 1
Oil form disclosed?	Not stated (“marine lipids”)	Yes – natural TG (TruTG™)
Digestion support	None listed	Lipase to improve absorption and reduce burps
Antioxidant	d-alpha-tocopheryl acetate	DeltaGold® tocotrienols
Purity / contaminant claims	Not listed	Molecularly distilled & filtered

The Best Fish Oils for Gut Health (Based on Potency, Purity, and Tolerability NOT Marketing Hype)

Because I never want to leave you hanging, I wanted to offer 2 alternatives to OmegaPlex, in case you are looking for a high-quality fish oil.

1. Nordic Naturals – ProOmega® 2000

This is the closest overall match to More Omega.

Why we chose it:

• Triglyceride (rTG) form = strong absorption
• High EPA + DHA levels (especially the 2X version)
• Wild-caught small-fish sourcing
• Very clean ingredients + excellent tolerability
• Industry-leading purity + transparency

Difference from More Omega: No added lipase or tocotrienols — but still our #1 pick.

2. Wiley’s Finest – Peak EPA

A strong second-place option.

Why it’s great:

• Triglyceride form
• High potency (approx. 1000 mg EPA+DHA per softgel)
• Excellent sustainability + USA-made
• Very clean testing profile

Difference from More Omega: No lipase/tocotrienols; more EPA-heavy.

Additional Solid Options

If the top two aren’t available or don’t fit your dosing style, these brands also tested well:

• Designs for Health – Omega Avail Hi-Po
• Pure Encapsulations – EPA/DHA Essentials
• Orthomolecular – OrthOmega
• Carlson Labs – Elite EPA Gems

You can get Carlson Labs + Pure Encapsulations via my Fullscript Online Dispensary.

You’ll find Designs for Health HERE.

And Orthomolecular HERE.

Fish Oil Comparison Table

Here’s a side-by-side breakdown of how these formulas stack up:

Brand	Form	EPA+DHA per Serving	Fish Source	Added Ingredients	AGG Rating
More Omega (discontinued)	rTG	1000+ mg	Small fish (anchovy/sardine)	Lipase, tocotrienols	⭐⭐⭐⭐⭐ Gold standard
Nordic Naturals ProOmega® 2000	rTG	640 mg (1280 mg for 2X)	Small fish (anchovy/sardine)	Minimal	⭐⭐⭐⭐⭐ Closest match
Wiley’s Finest Peak EPA	rTG	~1000 mg	Small fish	Minimal	⭐⭐⭐⭐⭐ High potency
Carlson Labs EPA Gems	TG	1000 mg EPA	Small fish	Minimal	⭐⭐⭐⭐ Clean option
Designs for Health Omega Avail Hi-Po	TG/rTG	800 mg EPA 800 mg DHA	Small fish	Minimal	⭐⭐⭐⭐ Professional grade
Pure Encapsulations EPA/DHA	TG	300 mg EPA 200 mg DHA	Small fish	Hypoallergenic	⭐⭐⭐⭐ Sensitive systems
Orthomolecular OrthOmega	TG	430 mg EPA 390 mg DHA 130 mg (additional Omega-3s)	Small fish	Minimal	⭐⭐⭐⭐ Professional grade
AdvoCare OmegaPlex	Not specified (likely EE)	600 mg EPA 400 mg DHA	Not emphasized	Various	⭐⭐ Not optimal for gut issues

The Bottom Line

Here’s what you need to remember:

Fish oil quality matters — especially when your gut is already struggling.

The difference between a mediocre fish oil and a truly effective one comes down to:

• Form (triglyceride wins every time for absorption)
• Potency (1000-1500 mg EPA+DHA is therapeutic)
• Source (small fish = cleaner)
• Purity (third-party testing is non-negotiable)

OmegaPlex is fine — but for women with gut issues, you need more than fine. You need clean, potent, absorbable, trustworthy.

More Omega delivered that for thousands of you, and while it’s no longer available, the good news is this: You still have excellent options.

And you don’t have to guess your way through the supplement aisle anymore.

If your healing feels slow… if inflammation feels stubborn… if hormones feel off… omega-3s can be part of your foundation.

Just choose the form your gut actually uses.

If you liked this article, you might also enjoy:

1. Best Autoimmune Supplements
2. DHA vs EPA [Episode 73, Bites 19]
3. Home Remedies for Leaky Gut (31 Specific Things to Heal a Leaky Gut)

Xox,
SKH